The Django cache middleware is great, but has one drawback. If you are caching views (which can give a nice performance boost) Django will only use the path segment of the URL to create a cache key. If you are an avid reader of RFC 3986 you may remember that a URI consists of multiple components; path and query being of special interest here. The problem is documented in ticket 4992 (Update: it is now in Django)....
I have been playing with YSlow, Yahoo’s tool for web site profiling, for a while. If you haven’t tried YSlow (which is a Firefox addon to Firebug) I recommend you try it right away. Install the Firebug extension first and then add YSlow. It is amazing how much you can improve the percieved site speed by some minor changes to your htaccess file. This site runs Wordpress and I was tempted to install the WP-Super-Cache plugin but was put off by some of the incompatibility issues that were reported with the latest version of Wordpress and PHP safe mode....